Hygiene of populated placesISSN: 2707-0441 eISSN: 2707-045X
Issue 71, 2021   -   Pages: 201-209
.. Biletska1, N.M. Onul1, V.V. Kalinicheva1, H.M. Yuntunen2

: 614.78:616-036.3+616-008.64:577.118]-021-084

Objective. Development of comprehensive measures for individual prevention of dyslementosis in the population of the ecologically crisis area.
Research results and their discussion. The article presents a developed system of prophylactic measures to prevent the development of dyslementosis in the population of man-made contaminated areas. The methodical approach of the proposed system is based on a complex combination of the main directions of general and individual prevention, among which the main attention is paid to medical and biological measures, i.e. secondary prevention. This approach involves a phased system to detect changes in elemental status in humans, prenosological changes in the body, followed by correction of micro- and macronutrient status by selecting appropriate foods and diets, the use of enterosorbents based on pectins, diet and drugs, but taking into account the history, clinical contraindications, based on biomonitoring and under constant medical supervision.
Conclusions. The most optimal and safe is the correction of nutrition by selecting the appropriate foods. The use of individual bioprophylaxis means - enterosorbents based on pectins are recommended to the greatest extent, since they bind and exclude xenobiotics from the body, are well tolerated, have no contraindications and have high clinical and hygienic efficiency. At the expressed deficiency of minor substances in a food it is necessary to apply dietary preparations and even drugs. The choice for each person should be made taking into account the anamnesis, clinical contraindications, based on biomonitoring, under the constant supervision of a physician.

dyselementoses, prevention, health, population, industrial cities.

1. Beletskaya E.N., Onul N.M. Ekologo-gigienicheskaya otsenka antropogennoy nagruzki okruzhayushchey sredy, kak faktora riska dlya zdorovya naseleniya Pridneprovya [Ecological and Hygienic Assessment of the Anthropogenic Load of the Environment as a Risk Factor for the Health of the Population of the Dnieper Region]. Dnepropetrovsk : Akcent. 2016 : 140 p. (in Russian).
2. Jessica Briffa, Emmanuel Sinagra, Renald Blundell. Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon. 2020 ; 6 (9) : e04691. DOI : https://doi.org/10.1016/j.heliyon.2020.e04691
3. Biletska E.M., Onul N.M., Horbachov D.M., Kalinicheva V.V. Profilaktyka rozvytku dyselementoziv u naselennia tekhnohenno zabrudnenykh terytorii: metod. rek. MOZ Ukrainy [Prevention of the Development of Dyslementosis in the Population of Man-Made Contaminated Areas: Guidelines of the Ministry of Health of Ukraine]. Dnipro. 2018 : 40 p. (in Ukrainian).
4. Sall M.L., Diaw A.K.D., Gningue-Sall D. et al. Toxic heavy metals: impact on the environment and human health, and treatment with conducting organic polymers, a review. Environ. Sci. Pollut. Res. Int. 2020 ; 27 : 29927-29942. DOI : https://doi.org/10.1007/s11356-020-09354-3
5. Trakhtenberh I.M., Chekman I.S., Lynnyk V.O. et al. Vzaiemodiia mikroelementiv: biolohichnyi, medychnyi i sotsialnyi aspekt [Interaction of Microelements: Biological, Medical and Social Aspect]. Visnyk natsionalnoi akademii nauk Ukrainy [Bulletin of the National Academy of Sciences of Ukraine]. 2013 ; 6 : 11-21 (in Ukrainian). DOI : https://doi.org/10.15407/visn2013.06.011
6. Rahman M.M., Hossain K.F.B., Bani S. et al. Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: A review. Ecotoxicology and Environmental Safety. 2019 ; 168 : 146-163. DOI : https://doi.org/10.1016/j.ecoenv.2018.10.054
7. Wei Wu, Ping Wu, Fang Yang et al. Assessment of heavy metal pollution and human health risks in urban soils around an electronics manufacturing facility. Science of The Total Environment. 2018 ; 183 : 53-61. DOI : https://doi.org/10.1016/j.scitotenv.2018.02.183
8. Shafran L.M., Pykhteeva E.G., Bolshoy D.V. Metallotioneiny [Metallothioneins]. L.M. Shafran (ed.). Odessa : Izdatelstvo "Chornomorya". 2011 : 428 p. (in Russian).
9. Hana R. Alzahrani, Hope Kumakli, Ampiah E. et al. Determination of macro, essential trace elements, toxic heavy metal concentrations, crude oil extracts and ash composition from Saudi Arabian fruits and vegetabls having medicinal values. Arabian Journal of Chemistry. 2017 ; 10 (7) : 906-913. DOI : https://doi.org/10.1016/j.arabjc.2016.09.012
10. Beletskaya E.N., Onul N.M. Selen v okruzhayushchey srede: ekologo-gigienicheskie aspekty problemy: monografiya. 2-e izd., pererabot. i dopoln. Dnepr [Selenium in the Environment: Ecological and Hygienic Aspects of the Problem: Monograph. 2nd ed., Revised. and Add.]. 2020 : 332 p. (in Russian).
11. Sall M.L., Diaw A.K.D., Gningue-Sall D. et al. Toxic heavy metals: Impact on the environment and human health, and treatment with conducting organic polymers, a review. Environ. Sci. Pollut. Res. Int. 2020 ; 27 : 29927-29942. DOI : https://doi.org/10.1007/s11356-020-09354-3
12. Demchenko P.I., Trakhtenberh I.M., Demchenko V.F., Nazarenko O.P. Pektynovmisni preparaty dlia bioprofilaktyky u vyrishenni problem khimichnoi bezpeky [Pectin-Containing Drugs for Bioprophylaxis in Solving Chemical Safety Problems]. In : Materialy informatsiino-komunikatyvnoho zakhodu 22-23 veresnia 2015 roku m. Kyiv [Materials of the Information and Communication Event on September 22-23, 2015 in Kyiv]. Kyiv : Ministry of Education and Science of Ukraine. 2015 : 120-122 (in Ukrainian).
13. Chekman I.S., Ulberh Z.R., Rudenko A.D. Tsynk i nanotsynk: vlastyvosti, zastosuvannia v klinichnii praktytsi [Zinc and Nanozinc: Properties, Application in Clinical Practice]. Ukr. medychnyi chasopys [Ukrainian Medical Journal]. 2013 ; 94 (2) : 45-47 (in Ukrainian).
14. Sujka M., Pankiewicz U., Kowalski R. et al. Determination of the content of Pb, Cd, Cu, Zn in dairy products from various regions of Poland. Open Chemistry. 2019 ; 17 (1) : 694-702. DOI : https://doi.org/10.1515/chem-2019-0072
15. Hulich M.P. Ratsionalne kharchuvannia ta zdorovyi sposib zhyttia osnovni chynnyky zberezhennia zdorovia naselennia [Nutrition and a Healthy Lifestyle are the Main Factors in Maintaining the Health of the Population]. Problemy stareniya i dolgoletiya [Aging and Longevity Problems]. 2011 ; 20 (2) : 128-132 (in Ukrainian).
16. Biletska E.M., Chekman I.S., Onul N.M. et al. Bioprotektorna diia tsynku v makro- i nanoakvakhelatnii formi na embriohenez shchuriv za umovy svyntsevoi intoksykatsii [Bioprotective Effect of Zinc in Macro- and Nano-Aquachelate Form on Rat Embryogenesis under Lead Intoxication]. Medychni perspektyvy [Medicni Perspektivi]. 2013 ; 18 (2) : 114-119 (in Ukrainian). DOI : https://doi.org/10.26641/2307-0404.2013.2.15983
17. Satarug S., Gobe G.C., Vesey D.A., Phelps K.R. Cadmium and lead exposure, nephrotoxicity, and mortality. Toxics. 2020 ; 8 : 1-42. DOI : https://doi.org/10.3390/toxics8040086

Biletska .., Onul N.M., Kalinicheva V.V., Yuntunen H.M. Hihiienichni zakhody profilaktyky dyselementoziv u naselennia promyslovykh mist [Hygienic Measures for the Prevention of Dyslementosis in the Population of Industrial Cities]. In : Hihiiena naselenykh mists : zb. nauk. pr. [Hygiene of Populated Places]. Kyiv ; 2021 ; 71 : 201-209 (in Ukrainian).